Nat Med | ʻO kahi ala nui e pili ana i ka hoʻopiliʻana i ka tumor hoʻohui

Nat Med | ʻO kahi neʻe lehulehu e hoʻonāukiuki i ka tumor i hoʻohuiʻia,ʻo ka michune a me nā michune a me nā michune a me nā microbialcape o ka micro colcorst
ʻOiaiʻo Biormars no ka nui o ka Calnice Cancer Cancer i aʻoʻia i nā makahiki i hala aku nei, a me nā kiʻina o DNA Ua loaʻa i nā mea noiʻi i ka hemahema o ka huiʻana ma waena o nā mea e pili ana i ka hana a me nā michune style genmune a me nā mea maʻi corrta ma ka corcer cheror corm

E hoʻomaikaʻiʻia ka noiʻiʻana,ʻo nā hiʻohiʻona nui o ka maʻi Cancevel Coffire Colocurs, e pili ana i keʻano o ka Clinical, akā, heʻano hoʻohālike o keʻano o ka Clincial
E wehe i ka pilina ma waena o Phenotypic Scellxity a me ka hopena, kahi hui o nā mea noiʻi ma keʻano he nui o nā mea kūʻai aku Hanaʻia ka hui i kahi hōʻike genomen genreative gefen frozen mai 348 mau mea maʻi i ka chequrect. Ua paʻiʻia ke aʻoʻana ma ka lāʻau lapaʻau ma keʻano he "he tumor i hoʻohuiʻia, helmune a me nā micmine a me nā micrubome atlas o ka calcus".

Kumuhana i paʻiʻia ma ka lāʻau lapaʻau kūlohelohe

AC-iCAM

Ua hoʻohanaʻia nā mea noiʻi i kahi kahua genhogona orthoconal e loiloi i nā kiʻiʻoniʻoni maikaʻi loa a me nā mea maʻi maʻi color Hoʻokumuʻia ma luna o ka SEQUENCE holoʻokoʻa (Wes), RNA-Seq Seq Score Chove ʻO ka hui noiʻi i kapaʻiaʻo ia kēia kumuwaiwai Sidra-lumc ac-iCam: kahi palapala'āina a me ke alakaʻi i ka micmat

Molecular Classification e hoʻohana ana i ICR

Ka hopuʻana i kahi papa inoa o nā manu haʻahaʻa o nā maʻi genetics no ka hoʻomau mauʻana i ka hana kolohe. Ua kāheaʻiaʻo Melanoma Ua hui pūʻiaʻo iCR me ka paneʻana o ka immuolotheraray i nāʻano mea kolohe, e komo pū me ka umauma umauma.

ʻO ka mea mua, ua hōʻoia nā poʻe noiʻi i ka hōʻailona o ICR i ka Chort Classing: E ​​hoʻohana ana i kahiʻano o ka counter counter Nā mea noiʻi i hōʻikeʻia i ka waiwai o ka maʻi i pili i nā counterus molekula mollecular (cms) Hoʻokomoʻia nā'āpana CMS1 / IMMUNE, CMS2 / Camisical, CMS3 / Metabolil a me CMS4 / Metenchioli. Ua hōʻike maikaʻiʻia ka loiloiʻana i nā helu ICR me kekahi mau ala cell cell cell i nā subfypsed a me nā ala e pili ana i nā gommutal.

I nā CMS a pau,ʻo ka nui o ka mea pepehi kanaka (NK) i nā mea eʻoi aku ka nui o nā subtypes'ē aʻe

Kiʻi 1.ʻO ka hoʻolālā haʻawina AC-iCam e pili ana,ʻo ka inoa inoaʻo Douge Genek,ʻo nā mollune a me nā molecular a me nā molecular subtypes a me nā mika.
Ua pioʻo ICR i ka tumor
ʻO ka liʻiliʻi wale nō o nā cell infilterating Tumor Tissue i hōʻikeʻia e pili ana i ka kiko'ī No laila,ʻo ka hapa nui o nā cells intra-tumor t e kapaʻia e like me nā cell cell (bystander t cell). ʻO ka hoʻoponopono ikaika loa me ka helu o nā cell conventiol i ka cell me nā tcr i nānāʻia ma nā subpopulations subpopular I loko o nā clusters ocr (ivererall a me ka cm papa),ʻoi aku ka nui o ka cosnality o nā tcr ter1 / cams subtypion Me ka hoʻohanaʻana i ka transcriptome āpau (18,270 mau genes),ʻeono mau genr genes Uaʻoi aku ka maikaʻi o ka cloglity tcr collality iʻoi aku ka ikaika me ka hapa nui o nā gennes ma mua o ka hoʻohanaʻana i nā cd8 + hōʻailona 2f a me 2g). I ka hopena, hōʻikeʻia ka loiloi i luna aʻe i nā inoa inoa iʻikeʻia i ka heleʻana o ka tumor-inika a iʻole e wehewehe i kāna mau mea hōʻoia.

Kiʻi 2.ʻO TCR Metric a me ke kaulike me nā GenMune-e pili ana i nā genes
Microbiome composition ma ke olakino olakino a me nā colon kane
Hana nā mea noiʻi i nā 16s rrna seequing me ka hoʻohanaʻana i ka dna i laweʻia mai ka tumor a me ke olakino olakino No ka hōʻoiaʻana, ua hoʻonuiʻia nā mea noiʻi he 16s rrna Gequing i kaʻikepili mai kahi mau helu he 42 mau hana maʻamau i loaʻaʻoleʻia. ʻO ka mua, ua hoʻokaʻawale nā ​​mea noiʻi i ka nui o flora ma waena o ka nui o nā fums otched a me ke olakino clon i loko. Ua hoʻonui nuiʻiaʻo Clstridium Perfingns i nā mea he nui i hoʻohālikelikeʻia i nā kiʻi olakino (kiʻi 3a-3d). ʻAʻohe meaʻokoʻa nui i ka alpha diversity (ka nui o nāʻano likeʻole ma waena o ka tumor a me nā mea hoʻonaninani maikaʻi loa i loko o ka tumor-kiʻekiʻe haʻahaʻa haʻahaʻa loa.
Eʻike i nā hui kūpono e pili ana i nāʻoihana micricial ma waena o nā microbial a me nā mea e like me nā mea noiʻi e hoʻohana ai i nā kiʻina o nā microbome e hoʻohana i ke ola. I Ac-iCam246, holo aku nā mea noiʻi i kahi kumuwaiwai COX Regression Modents
I loko o kēia chort aʻo chort (igam246), kahi huahelu haʻahaʻa haʻahaʻa mbr (mbr <0, low mbr) me kahi haʻahaʻa haʻahaʻa haʻahaʻa o ka make (85%). Ua hōʻoia ka poʻe noiʻi i ka hui ma waena o ka nui o ka mbr (scolsed) a me ka lōʻihi) a me nā mea paʻa i loko o nā cohor i hōʻoiaʻia iʻelua mau coherted coad). (Kiʻi 3) hōʻike i ke aʻoʻana i kahi hoʻoponopono ikaika ma waena o nā helu cocci a me nā'āpana a me ka tumor.

Kiʻi 3.ʻO Microbiome i Tumor a me ke olakino olakino a me ka pilina me nā mea maʻi a me ka mea ola.
Hopena
ʻO ka heleʻana o nā mea hoʻonaninani nui i hoʻohanaʻia ma kēia noiʻi e hiki ai i kaʻike a me ka nānāʻana o ka hōʻailona mole i waena o ka micune. ʻO ka tcr tcr sequencing o Tumor a me ke olakino e hōʻikeʻia ana ka hopena prognostic o ICR ma muli o kona hiki ke hopu i ka colnes antigen

Ma ka nānāʻana i ka hoʻokūkū michuboupome e hoʻohana ana i nā 16s rrna Gequing i nāʻano hōʻike Ac-ICam i hōʻikeʻia (MRR ʻOiai ua loaʻa kēia inoa inoa me ka nui o nā kolohe, heʻano ikaika ma waena o ka counter maikaʻi, eʻike paha i kēia kau inoa o ka maʻi miki pāpaʻi. Ma ka hoʻohuiʻana i nā helu ICR a me MBR, hiki ke hoʻomaopopo a hōʻoia i ka biorker lehulehu nui i nā mea maʻi me nā maʻi coloncy. Hāʻawi kaʻikepili o ka Storm-omic

Kākau:
Roendore, J., Kuppen, Pjk, PJK, PJK, EI e me Et Al. ʻO kahiʻano e hoʻopili ai, irmune a me nā microbio a me nā microbiot atlas o ka color cancer. N Meto 29, 1273-1286 (2023).