ʻO nā poʻe maʻi maʻi maʻi ʻāʻī, pono anei ka hoʻāʻo ʻana iā MRD?

ʻO MRD (Minimal Residual Disease), a i ʻole Minimal Residual Disease, he helu liʻiliʻi o nā pūnaewele maʻi maʻi ʻaʻole pane a kū ʻole paha i ka mālama ʻana) e waiho nei i loko o ke kino ma hope o ka mālama ʻana i ka maʻi kanesa.
Hiki ke hoʻohana ʻia ʻo MRD ma ke ʻano he biomarker, me ka hopena maikaʻi ʻo ia hoʻi, hiki ke ʻike ʻia nā koena liona ma hope o ka mālama ʻana i ka maʻi kanesa (loaʻa nā cell cancer, a hiki ke hoʻoikaika a hoʻomaka ka hoʻonui ʻana ma hope o ka mālama ʻana i ka maʻi kanesa, e alakaʻi ana i ka hoʻi hou ʻana o ka maʻi kanesa. maʻi), ʻoiai ʻo ka hopena maikaʻi ʻole ʻaʻole i ʻike ʻia nā koena liona ma hope o ka mālama ʻana i ka maʻi maʻi (ʻaʻole ʻike ʻia nā maʻi kanesa);
Ua ʻike maopopo ʻia he kuleana koʻikoʻi ka hoʻāʻo ʻana iā MRD i ka ʻike ʻana i nā maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i ka nui o ka hoʻi hou ʻana a i ke alakaʻi ʻana i ka lāʻau adjuvant ma hope o ke kaʻina radical.
Nā hiʻohiʻona i hiki ke hoʻohana ʻia iā MRD:

No ka hoʻohana ʻana i ka maʻi kanesa maʻi maʻi mua

1. Ma hope o ka wehe ʻana i nā mea maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi i nā maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi, ʻo ka MRD positivity e hōʻike ana i kahi pilikia nui o ka hoʻi hou ʻana a koi ʻia ka mālama ʻana i ka hahai ʻana. Manaʻo ʻia ka nānā ʻana o MRD i kēlā me kēia 3-6 mahina;
2. Manaʻo ʻia e hoʻokō i nā hoʻokolohua lapaʻau perioperative o ka maʻi maʻi ʻaʻai māmā liʻiliʻi liʻiliʻi ma muli o MRD, a hāʻawi i nā koho lapaʻau perioperative e like me ka hiki;
3. Manaʻo e ʻimi i ke kuleana o MRD i nā ʻano maʻi ʻelua, ʻo ke kumu hoʻokele maikaʻi a me ke kumu hoʻokele maikaʻi ʻole, ʻokoʻa.

No ka ma'i 'a'ai ma'i 'a'ai 'ole li'ili'i

1. Manaʻo ʻia ka hoʻāʻo ʻana o MRD no nā poʻe maʻi i ke kala piha ʻana ma hope o ka chemoradiotherapy radical no ka maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi kūloko, hiki ke kōkua i ka hoʻoholo ʻana i ka prognosis a hoʻolālā i nā hoʻolālā lapaʻau hou aʻe;
2. Manaʻo ʻia nā hoʻokolohua lapaʻau o MRD-based consolidation therapy ma hope o ka chemoradiotherapy e hāʻawi i nā koho consolidation therapy pololei e like me ka hiki.
No ka ma'i 'a'ai ma'i ma'i 'ole li'ili'i
1. Loaʻa ka nele o nā haʻawina kūpono e pili ana i ka MRD i ka maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi;
2. Manaʻo ʻia e ʻike ʻia ʻo MRD i nā poʻe maʻi i ke kala piha ʻana ma hope o ka hoʻomaʻamaʻa ʻōnaehana no ka maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi, hiki ke kōkua i ka hoʻoponopono ʻana i ka wānana a hoʻomohala i nā hoʻolālā therapeutic hou;
3. Manaʻo ʻia e hana i ka noiʻi ʻana i nā hoʻolālā lapaʻau e pili ana i ka MRD i ka poʻe maʻi i ke kala piha ʻana e hoʻolōʻihi i ka lōʻihi o ke kala piha e like me ka hiki i hiki i nā maʻi ke hoʻonui i kā lākou mau pono.

Hiki ke ʻike ʻia ma muli o ka nele o nā haʻawina pili e pili ana i ka ʻike ʻana i ka MRD i ka maʻi maʻi ʻaʻai maʻi ʻaʻole liʻiliʻi liʻiliʻi, ʻaʻole i hōʻike maopopo ʻia ka noi ʻana o ka ʻike MRD i ka mālama ʻana i nā maʻi maʻi maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi.
I nā makahiki i hala iho nei, ua hoʻololi ka holomua o ka mea i hoʻopaʻa ʻia a me ka immunotherapy i ka nānā ʻana i ka mālama ʻana no nā maʻi me ka NSCLC kiʻekiʻe.
Hōʻike nā hōʻike e puka mai ana e loaʻa i kekahi mau maʻi ke ola lōʻihi a manaʻo ʻia e loaʻa i ke kala piha ʻana ma ke kiʻi. No laila, ma lalo o ka manaʻo o kekahi mau pūʻulu o nā mea maʻi me ka NSCLC kiʻekiʻe ua hoʻomaopopo mālie i ka pahuhopu o ke ola lōʻihi, ua lilo ka nānā ʻana i ka maʻi maʻi i mea koʻikoʻi koʻikoʻi, a inā hiki i ka hoʻāʻo MRD ke pāʻani i kahi kuleana koʻikoʻi i loko o ia mea e pono ke ʻimi ʻia. i nā hoʻokolohua lapaʻau hou aku.