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Lawe kekahi mau ʻīlio i nā lāʻau antiparasitic me ka pilikia ʻole, aʻo kekahi e ulu anaka luaʻi a me ka ʻōpū. Hiki iā ʻoe ke hāʻawi i kāu ʻīlio i lāʻau ʻeha e like me kona kaumaha, akā ʻaʻohe hopena a haʻalele paha kāu pipi i ka lethargic. — Pili loa paha keia i kaʻano kūʻē kūʻē i nā lāʻau nui (MDR1)ma ke kino o ka ilio.
ʻO kēia "mea hoʻoponopono ʻike ʻole" o ka metabolism lāʻau e paʻa i ke kī i ka palekana o ka lāʻau lapaʻau no nā holoholona, aMDR1 gene nucleic acid ho'āʻoʻo ia ke ala koʻikoʻi no ka wehe ʻana i kēia code.
ʻAʻOLE. 1
ʻO ke kī i ka palekana lāʻau: ʻo ka MDR1 Gene
No ka hoʻomaopopo ʻana i ke koʻikoʻi o ka gene MDR1, pono mākou e ʻike mua i kāna "hana nui" - e hana ana ma ke ʻano he mea lawe kaʻa o ka metabolism lāʻau. ʻO ka MDR1 gene ke alakaʻi i ka synthesis o kahi mea i kapa ʻia ʻo P-glycoprotein, ka mea i māhele nui ʻia ma ka ʻili o nā cell i loko o ka ʻōpū, ate, a me nā puʻupaʻa. Hana ʻia e like me kahi hale lawe lāʻau lapaʻau i hoʻolaʻa ʻia:
Ma hope o ka lawe ʻana o ka ʻīlio i ka lāʻau lapaʻau, hoʻopuka ka P-glycoprotein i nā lāʻau ʻoi loa mai loko mai o nā keena a kipaku aku iā lākou ma o ka feces a i ʻole ka mimi, e pale ana i ka hōʻiliʻili ʻino i loko o ke kino. Mālama pū ia i nā kino koʻikoʻi e like me ka lolo a me ka iwi iwi ma o ka pale ʻana i ke komo nui ʻana o ka lāʻau i hiki ke hōʻino.
Eia naʻe, inā hoʻololi ka MDR1 gene, hoʻomaka kēia "mea lawe lima" e hana hewa. Hiki ke ho'oikaika 'ia, e puhi koke i ka lā'au a lawa 'ole ke koko, e ho'emi loa i ka pono o ka lā'au. A i ʻole he hana ʻino paha, ʻaʻole hiki ke hoʻomaʻemaʻe i nā lāʻau lapaʻau i ka manawa, e hōʻiliʻili ai nā lāʻau a hoʻoulu i nā hopena ʻaoʻao e like me ka luaʻi ʻana a i ʻole ke akepaʻa a me ke kīkī.— ʻO ia ke kumu e hiki ai i nā ʻīlio ke pane ʻokoʻa i ka lāʻau lapaʻau like.
ʻOi aku ka piliʻO ia ka hana ʻana o nā mea ʻino MDR1 e like me "nā ʻāina ʻāina" huna - ʻaʻole hiki ke ʻike ʻia a hiki i ka lāʻau lapaʻau ke hoʻomaka i ka pilikia. No ka laʻana, hānau ʻia kekahi mau ʻīlio me nā genes MDR1 kīnā ʻole, a ʻo nā kumu maʻamau o nā lāʻau antiparasitic (e like me ivermectin) hiki ke hoʻoulu i ka ataxia a i ʻole coma ke hāʻawi ʻia i ka wā ʻōpio. Hiki i nā ʻīlio ʻē aʻe me ka hana MDR1 ʻoi aku ka maikaʻi o ka ʻeha mai ka opioids ʻoiai ke kau ʻia ma ke kaumaha. ʻAʻole kēia mau pilikia ma muli o "nā lāʻau lapaʻau maikaʻi ʻole" a i ʻole "nā ʻīlio hui ʻole," akā i ka mana o nā genetics.
Ma ka hoʻomaʻamaʻa lāʻau lapaʻau, nui nā holoholona i loaʻa i ka hōʻino ʻino a i ʻole ka hōʻino neurological ma hope o ka lawe ʻana i ka lāʻau lapaʻau me ka ʻole o ka nānā ʻana i ka MDR1 - ke alakaʻi nei ʻaʻole wale i nā kumukūʻai lapaʻau kiʻekiʻe akā ʻo ka ʻeha pono ʻole no nā holoholona.
ʻAʻOLE. 2
Ho'āʻo Genetic no ka pale ʻana i nā pilikia o ka lāʻau
ʻO Canine MDR1 gene nucleic acid ka hoʻāʻo ʻana i ke kī i ka hoʻomaopopo ʻana i ke "kūlana hana" o kēia transporter ma mua. ʻAʻole e like me ka nānā ʻana i ke koko kuʻuna - pono e huki pinepine ʻia ke koko ma hope o ka lāʻau lapaʻau - ke kālailai pololei nei kēia ʻano i ka gene MDR1 o ka ʻīlio e hoʻoholo ai inā loaʻa nā hoʻololi a me ke ʻano o lākou.
He maʻalahi ka loiloi a like me ka hoʻāʻo genetic hyperthermia malignant, ʻekolu mau ʻanuʻu nui:
1. ʻOhi Laʻana:
Ma muli o ka loaʻa ʻana o ka gene MDR1 i loko o nā pūnaewele a pau, pono kahi laʻana koko liʻiliʻi a i ʻole ka waha waha.
2. Ka unuhi ʻana o DNA:
Ke hoʻohana nei ke keʻena hana i nā mea hoʻokalakupua kūikawā e hoʻokaʻawale i ka DNA o ka ʻīlio mai ka laʻana, e wehe ana i nā protein a me nā haumia ʻē aʻe no ka loaʻa ʻana o kahi hoʻohālike genetic maʻemaʻe.
3. Hoʻonui a me ka nānā ʻana o PCR:
Me ka hoʻohana ʻana i nā ʻimi kikoʻī i hoʻolālā ʻia no nā pae hoʻololi nui MDR1 (e like me ka mutation canine nt230[del4] maʻamau), hoʻonui ʻo PCR i ka ʻāpana gene i manaʻo ʻia. A laila ʻike ka mea kani i nā hōʻailona fluorescent mai ka ʻimi noiʻi e hoʻoholo i ke kūlana mutation a me ka hopena hana.
ʻO ke kaʻina holoʻokoʻa ma kahi o 1-3 mau hola. Hāʻawi nā hualoaʻa i ke alakaʻi pololei no nā mea lapaʻau, e ʻae ana i nā koho lāʻau palekana a ʻoi aku ka pololei ma mua o ka hilinaʻi ʻana i ka hoʻāʻo-a-hewa.
ʻAʻOLE. 3
Nā ʻokoʻa Genetic Innate, Loaʻa i ka palekana lāʻau
E noʻonoʻo paha ka poʻe nona nā holoholona: ʻO MDR1 nā mea ʻino a i loaʻa paha?
ʻElua mau kumu nui, me ka genetics ka mea mua:
Nā ʻano Genetic Lahui-Specific
ʻO kēia ke kumu maʻamau. He ʻokoʻa ka nui o ka hoʻololi ʻana i nā ʻano like ʻole:
- Collies(me nā Shetland Sheepdogs a me Border Collies) he kiʻekiʻe loa ka nt230[del4] mutation rate - ma kahi o 70% o nā Collies purebred e lawe i kēia hemahema.
- Kahuhipa AustraliaaNā ʻīlio hipa Pelekane kahikohōʻike pū i nā uku kiʻekiʻe.
- ʻO nā ʻano likeChihuahuasaPoodlesloaʻa nā helu hoʻololi haʻahaʻa haʻahaʻa.
ʻO ia hoʻi, inā ʻaʻole i lawe ka ʻīlio i ka lāʻau lapaʻau, hiki i nā ʻano ʻano kiʻekiʻe ke lawe i ka mutation.
ʻO nā lāʻau lapaʻau a me nā hopena o ke kaiapuni
ʻOiai ʻo ka MDR1 gene ponoʻī he ʻano maoli, hiki i ka hoʻohana lōʻihi a koʻikoʻi paha i kekahi mau lāʻau lapaʻau ke "hoʻoulu" i ka hōʻike gene abnormal.
Hoʻohana lōʻihi o kekahinā lāʻau lapaʻau(e laʻa, nā tetracyclines) a i ʻoleimmunosuppressantshiki ke kumu i ka overactivity compensatory o MDR1, hoʻohālike i ke kūʻē ʻana i ka lāʻau me ka ʻole o ka mutation maoli.
Hiki i kekahi mau kemika kaiapuni (e like me nā mea hoʻohui i loko o nā huahana holoholona maikaʻi haʻahaʻa) hiki ke hoʻopilikia ʻole i ke kūpaʻa gene.
Hoʻopili ka MDR1 gene i kahi ākea ākea o nā lāʻau lapaʻau, me nā lāʻau antiparasitic, nā mea hōʻeha ʻeha, nā antibiotic, nā lāʻau chemotherapy, a me nā lāʻau anti-epileptic. ʻo kahi laʻana:
Hiki i ka Collie ke lawe i ke kīnā ke loaʻa i ka neurotoxicity ma muli o ka nui o ka ivermectin.
Pono paha nā ʻīlio me ka MDR1 ʻoi aku ka hoʻoponopono ʻia o nā lāʻau antifungal no nā maʻi ʻili e loaʻa ai ka pono kūpono.
ʻO ia ke kumu i koʻikoʻi ai ka poʻe holoholona holoholona i ka nānā ʻana i ka MDR1 ma mua o ke kuhikuhi ʻana i nā ʻano ʻano kiʻekiʻe.
No nā mea mālama holoholona, hāʻawi ka hoʻāʻo ʻana o ka waika nucleic MDR1 i ʻelua pale no ka palekana o ka lāʻau lapaʻau:
ʻO ka hoʻāʻo ʻana i nā ʻano ʻano pilikia nui (e laʻa, ʻo Collies) e hōʻike ana i nā contraindications o ka lāʻau lapaʻau i ke ola a pale i ka make ʻino.
Hiki i nā ʻīlio ke koi nei i nā lāʻau lapaʻau lōʻihi (e like me ka ʻeha mau a i ʻole epilepsy) hiki ke hoʻoponopono pololei ʻia.
ʻO ka hoʻāʻo ʻana i ka hoʻopakele a i ʻole nā ʻīlio hui ʻia e wehe i nā kānalua e pili ana i nā pilikia genetic.
He waiwai nui ia no nā ʻīlio kahiko a i ʻole ka poʻe me nā maʻi maʻi mau, ka poʻe e koi pinepine i ka lāʻau lapaʻau.
ʻAʻOLE. 4
ʻO ka ʻike ma mua ʻoi aku ka maikaʻi o ka palekana
Ma muli o nā hopena hoʻāʻo, eia ʻekolu mau ʻōlelo aʻoaʻo palekana lāʻau:
Pono e ho'āʻo mua ʻia nā ʻano ʻano kiʻekiʻe.
Pono nā Collies, Australian Shepherds, a me nā ʻano like ʻole e hoʻopau i ka hoʻāʻo MDR1 ma mua o 3 mau mahina a mālama i nā hopena ma ka faila me kā lākou kauka holoholona.
E nīnau mau i kāu kauka lapaʻau e pili ana i ka "genetic compatibility" ma mua o ka hāʻawi ʻana i ka lāʻau lapaʻau.
He mea koʻikoʻi kēia no nā lāʻau lapaʻau kiʻekiʻe e like me nā lāʻau antiparasitic a me nā lāʻau ʻeha. ʻOiai ʻaʻole pilikia nui ka ʻīlio o kāu ʻīlio, pono e noʻonoʻo ʻia ka moʻolelo o nā hopena ʻino.
E hōʻalo i ka lāʻau ponoʻī me nā lāʻau he nui.
Hiki i nā lāʻau lapaʻau ʻokoʻa ke hoʻokūkū no nā ala lawe o P-glycoprotein. Hiki i nā genes MDR1 maʻamau ke hoʻopilikia ʻia, e alakaʻi ana i ka metabolic imbalance a me ka hoʻonui ʻana i nā pilikia ʻona.
Aia ka pilikia o ka hoʻololi ʻana o MDR1 i ko lākou ʻike ʻole - huna ʻia i loko o ke kaʻina genetic, ʻaʻole hōʻike i nā hōʻailona a hiki i ka lāʻau lapaʻau ke hoʻomaka koke i kahi pilikia.
Hana ʻia ka hoʻāʻo ʻana o ka waika nucleic MDR1 e like me ka mea ʻike maka ʻāina, e kōkua ana iā mākou e hoʻomaopopo mua i ke ʻano o ka metabolism o ka ʻīlio. Ma ke aʻo ʻana i kāna ʻano hana a me nā ʻano hoʻoilina, ka hana ʻana i ka nānā mua ʻana, a me ka hoʻohana ʻana i nā lāʻau lapaʻau me ke kuleana, hiki iā mākou ke hōʻoia i ka wā e pono ai kā mākou mau puaʻa i ka mālama ʻana, loaʻa iā lākou ke kōkua kūpono ʻoiai e pale ana i nā pilikia lāʻau - mālama i ko lākou olakino ma ke ala kūpono loa.
Ka manawa hoʻouna: Nov-20-2025
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